解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Nucleostemin is a nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells. It has been proposed that nucleostemin may represent a valu...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-014-0072-6
更新日期:2014-09-12 00:00:00
abstract:BACKGROUND:Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertroph...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-12-25
更新日期:2014-03-27 00:00:00
abstract:BACKGROUND:The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd gen...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-12-12
更新日期:2014-02-14 00:00:00
abstract:BACKGROUND:Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-111
更新日期:2013-11-13 00:00:00
abstract:BACKGROUND:The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the functional role of gene-regulation sequences in health and disease. In thi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-106
更新日期:2013-10-14 00:00:00
abstract::The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, th...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/1741-7007-11-96
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-93
更新日期:2013-08-19 00:00:00
abstract:BACKGROUND:In HIV-1-infected human monocyte-derived macrophages (MDMs), virus particles assemble primarily on intracellularly sequestered plasma membrane domains termed intracellular plasma membrane-connected compartments (IPMCs). Despite their clear role in virus formation, little is known of the organization, composi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-89
更新日期:2013-08-02 00:00:00
abstract:BACKGROUND:Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mechanisms of the latter effects are unclear. The aim of this study was to determine the mechanisms by wh...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-88
更新日期:2013-08-01 00:00:00
abstract::The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/1741-7007-11-54
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:The pituitary gland is formed by the juxtaposition of two tissues: neuroectoderm arising from the basal diencephalon, and oral epithelium, which invaginates towards the central nervous system from the roof of the mouth. The oral invagination that reaches the brain from the mouth is referred to as Rathke's po...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-27
更新日期:2013-03-28 00:00:00
abstract:BACKGROUND:Drosophila melanogaster has served as a powerful model system for genetic studies of courtship songs. To accelerate research on the genetic and neural mechanisms underlying courtship song, we have developed a sensitive recording system to simultaneously capture the acoustic signals from 32 separate pairs of ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-11
更新日期:2013-01-31 00:00:00
abstract:BACKGROUND:Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. RESULTS:We d...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-10-96
更新日期:2012-11-30 00:00:00
abstract:BACKGROUND:Seed plants are composed of angiosperms and gymnosperms, which diverged from each other around 300 million years ago. While much light has been shed on the mechanisms and rate of genome evolution in flowering plants, such knowledge remains conspicuously meagre for the gymnosperms. Conifers are key representa...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-10-84
更新日期:2012-10-26 00:00:00
abstract:BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-10-80
更新日期:2012-09-28 00:00:00
abstract::Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/1741-7007-10-75
更新日期:2012-08-21 00:00:00
abstract::In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent ...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/1741-7007-10-48
更新日期:2012-06-13 00:00:00
abstract::The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-10-35
更新日期:2012-04-24 00:00:00
abstract::Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous e...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/1741-7007-10-2
更新日期:2012-01-25 00:00:00
abstract::The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/1741-7007-9-88
更新日期:2011-12-28 00:00:00
abstract::This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodolog...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/1741-7007-9-71
更新日期:2011-10-28 00:00:00
abstract::Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing the development of new drugs. Zhao and Vuori describe this month...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/1741-7007-9-72
更新日期:2011-10-28 00:00:00
abstract::The elevated metabolic requirements of cancer cells reflect their rapid growth and proliferation and are met through mutations in oncogenes and tumor suppressor genes that reprogram cellular processes. For example, in tuberous sclerosis complex (TSC)-related tumors, the loss of TSC1/2 function causes constitutive mTOR...
journal_title:BMC biology
pub_type: 社论,评审
doi:10.1186/1741-7007-9-69
更新日期:2011-10-21 00:00:00
abstract::Cells are highly complex and orderly machines, with defined shapes and a startling variety of internal organizations. Complex geometry is a feature of both free-living unicellular organisms and cells inside multicellular animals. Where does the geometry of a cell come from? Many of the same questions that arise in dev...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-9-57
更新日期:2011-08-31 00:00:00
abstract::There are many reasons to be interested in stem cells, one of the most prominent being their potential use in finding better drugs to treat human disease. This article focuses on how this may be implemented. Recent advances in the production of reprogrammed adult cells and their regulated differentiation to disease-re...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/1741-7007-9-42
更新日期:2011-06-07 00:00:00
abstract:BACKGROUND:Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized a...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-9-38
更新日期:2011-06-02 00:00:00
abstract:BACKGROUND:Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living cells. Recently, fluorescence resonance energy transfer (FRET) sensors...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-9-32
更新日期:2011-05-27 00:00:00
abstract:BACKGROUND:Archaeological studies have revealed a series of cultural changes around the Last Glacial Maximum in East Asia; whether these changes left any signatures in the gene pool of East Asians remains poorly indicated. To achieve deeper insights into the demographic history of modern humans in East Asia around the ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-9-2
更新日期:2011-01-10 00:00:00
abstract:BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-146
更新日期:2010-12-13 00:00:00
abstract:BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-142
更新日期:2010-11-30 00:00:00
abstract::The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the supe...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/1741-7007-8-126
更新日期:2010-09-28 00:00:00
abstract::A recent paper in BMC Structural Biology reports the crystal structure of human prolylcarboxypeptidase (PRCP), one of the two members of the S28 peptidase family. Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-87
更新日期:2010-06-28 00:00:00
abstract::A recent report in BMC Biology on the discovery and analysis of biosynthetic genes for ribosomal peptide natural products confirms that these pathways are much more common and diverse than previously suspected, contributing substantially to the chemical arsenal employed by bacteria. See research article http://www.bio...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/1741-7007-8-83
更新日期:2010-06-17 00:00:00
abstract:BACKGROUND:A new family of natural products has been described in which cysteine, serine and threonine from ribosomally-produced peptides are converted to thiazoles, oxazoles and methyloxazoles, respectively. These metabolites and their biosynthetic gene clusters are now referred to as thiazole/oxazole-modified microci...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-70
更新日期:2010-05-25 00:00:00
abstract::A recent paper published in BMC Genomics suggests that retrotransposition may be active in the human gut parasite Entamoeba histolytica. This adds to our knowledge of the various types of repetitive elements in parasitic protists and the potential influence of such elements on pathogenicity. ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-64
更新日期:2010-05-24 00:00:00
abstract:BACKGROUND:Phylostratigraphy is a method used to correlate the evolutionary origin of founder genes (that is, functional founder protein domains) of gene families with particular macroevolutionary transitions. It is based on a model of genome evolution that suggests that the origin of complex phenotypic innovations wil...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-66
更新日期:2010-05-21 00:00:00
abstract::The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analysis of the CCA1/LHY and TOC1/PRR gene families that the common ancestor of monocots and eudicots had compone...
journal_title:BMC biology
pub_type: 评论,杂志文章,评审
doi:10.1186/1741-7007-8-55
更新日期:2010-05-07 00:00:00
abstract::Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent paper in BMC Systems Biology describes a promising step in this direction. ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-48
更新日期:2010-04-28 00:00:00
abstract::The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in mediating these responses. See research article http://www.biomedcentra...
journal_title:BMC biology
pub_type: 评论,社论
doi:10.1186/1741-7007-8-47
更新日期:2010-04-27 00:00:00
abstract::The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, homoploid (diploid) hybridization may be just as common. Recent studies, including one in BMC Evolutionary Biolo...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/1741-7007-8-45
更新日期:2010-04-21 00:00:00